Vana-Antsla (German: Alt-Anzen) is a small borough (Estonian: alevik) in Võru County, in southeastern Estonia, located about 4 km (2 mi) north of the town of Antsla.

[1] The settlement is situated around the Vana-Antsla knight manor (Schloß Anzen), first mentioned in 1404.

At first it was built as a vassal's stronghold and belonged to the Uexküll family.

Swedish King Gustav II Adolf gave the manor to Åke Tott in 1625.

After the Great Northern War the manor was owned by the Löwenstern family and from 1883 by the Ungern-Sternbergs.