Vandzene Manor (Latvian: Vandzenes muižas pils, German: Herrenhaus Wandsen) is a manor house in Vandzene Parish, Talsi Municipality in the historical region of Courland, in western Latvia.

The manor ensemble was created for the family of Baron Heikings [de] in the middle of the 19th century.

In front of the manor palace is a front garden designed in 1937 by Andrejs Zeidaks, garden architect from Riga.

Since 1937, Vandzene Secondary School, originally founded in 1866, has been located in the manor palace.

This article about a castle, palace or manor house in Latvia is a stub.