She co-created, co-executive produced, and had the lead role in the Showtime comedy I Love That for You, loosely based on her experience as a survivor of childhood leukemia.

[4][10][11] While attending college, she interned on the television shows Sesame Street and Late Night with Conan O'Brien and participated in the cast of Bloomers, an all-female musical and sketch comedy troupe.

[12] As of 2012[update], Bayer was collaborating with her brother Jonah on the web series Sound Advice for Above Average, where she stars as Janessa Slater, a media coach who helps famous musicians change their images.

[citation needed] She performed improvisational comedy at Chicago's ImprovOlympic, where she trained with SNL castmate Paul Brittain,[3] and at the Annoyance Theatre and The Second City.

Bayer is the co-creator, co-executive producer and star of the Showtime comedy I Love That for You, which premiered on May 1, 2022, and is loosely based on her life as a survivor of childhood leukemia.

[21][22][23] Bayer appeared in two episodes of What We Do in the Shadows as Evie Summers, a vampire who drains energy from humans by resorting to passive aggressive and wholly fabricated stories of various horrible things that supposedly happened to her.