Beginning her career as a dancer, Bell Calloway became known for her film roles as Princess Imani Izzi in the 1988 comedy Coming to America and its sequel.

Bell Calloway appeared in films Death Spa (1988), What's Love Got to Do with It (1993), The Inkwell (1994), Crimson Tide (1995), Daylight (1996), The Brothers (2001) and Biker Boyz (2003).

Bell Calloway had several starring roles on television series and movies, include first African American prime time soap opera, Under One Roof (1995).

[2][3] It was during this time period that Bell Calloway directed the music video "Angel Man" for soul singer Rhetta Hughes.

After moving to Los Angeles in 1986, she began appearing in episodes of prime time shows such as The Colbys, Falcon Crest, 227, China Beach, A Different World, and L.A. Law.

She made her film debut on Number One with a Bullet (1987), before supporting role of Eddie Murphy's character's arranged wife in the 1988 comedy Coming to America.

During the 1990s, she had number of supporting roles in films, including What's Love Got to Do with It (1993) opposite Angela Bassett, The Inkwell (1994), and Crimson Tide (1995) as Denzel Washington's character wife.

She also had the leading roles on the short-leved NBC sitcom Rhythm & Blues (1992–93), and starred alongside Larry Hagman as his girlfriend in the CBS drama Orleans (1997).

Bell Calloway also guest starred on The Division, Strong Medicine, The Closer, CSI: Crime Scene Investigation, Dexter, Rizzoli & Isles, and Castle.