[2] Vanessa began playing the piano at the age of three, starting her comprehensive musical studies and giving her first public appearance at four years old.

[6] Later highlights include her debut at La Scala in Milan and Turin's Teatro Regio at the MiTo Festival; solo recitals at the Muziekgebouw in Amsterdam and at the Seoul Arts Center; chamber music with the Russian violinist Vadim Repin; a tour of China making solo debuts at Beijing National Centre for the Performing Arts, Harbin Grand Theater and Chongqing Guotai Arts Center among other venues; performances at Salle Gaveau in Paris, performing Chopin's Piano Concerto No.

Since making debuts at New York's Lincoln Center, Tonhalle, Zürich, and London's Wigmore Hall, Benelli Mosell has given concerts and solo recitals at Hamburg's Laeiszhalle, Berliner Philharmonie, Auditorio Nacional de Madrid, Palau de la Musica Catalana in Barcelona, Auditorio de Saragoza, Palau de la Musica in Valencia, Auditorium de Radio France and Auditorium du Louvre in Paris, Auditorium Manzoni in Bologna, Sala Verdi in Milan, Dublin National Concert Hall, Haifa Auditorium, Seoul Arts Center, Muziekgebouw Amsterdam, Harbin Grand Theater, Beijing NCPA, London's Royal Festival Hall and Kings Place, La Scala in Milano, Teatro Regio in Turin, Salle Poirel in Nancy, Corum in Montpellier, Théatre de la Criée in Marseille, Bavaria's Schloss Elmau, Glasgow Royal Concert Hall and Usher Hall in Edinburgh.

Benelli Mosell has collaborated with contemporary composers including George Benjamin, Hugues Dufourt, Stefano Gervasoni, Martin Matalon and Marco Stroppa.

As a chamber music performer she collaborated with Renaud and Gautier Capuçon, Julian Rachlin, Vadim Repin, Massimo Quarta, Daishin Kashimoto, Radovan Vlatkovich and his partner the French cellist Henri Demarquette, with whom she released the album Echoes for Decca, a juxtaposition of works by Philip Glass and Sergei Rachmaninoff for cello and piano.