Varenne-Saint-Germain (French pronunciation: [vaʁɛn sɛ̃ ʒɛʁmɛ̃]) is a commune in the Saône-et-Loire department in the region of Bourgogne-Franche-Comté in eastern France.

Varenne-Saint-Germain is bordered by the Digoin commune to the north, Vitry-en-Charollais to the east, Saint-Yan to the south and Chassenard to the west.

The Arconce flows north-northwest through the middle of the commune, then flows into the Loire, which forms parts of the commune's western border.

In 1793, during the French Revolution, Reuillon, hamlet of Varennes-Reuillon, was renamed to La Montagne.

[2] During the Second World War, the commune was crossed by the demarcation line; the remains of a border post are still present on the road D982.