[2] Vasantrao Deshpande was born into a Deshastha Brahmin family[3] in Murtizapur, Akola District, in the Vidarbha region of Maharashtra in India.

At the age of eight, Vasantrao Deshpande's ability was observed by Bhalji Pendharkar, who cast him in the role of Krishna in the Hindi movie Kaliya Mardan (1935).

[8] Deshpande performed classical and semi-classical music, appearing in movies including Kaliya Mardan, Dudh Bhaat, and Ashtavinayak.

[17][18] In 2011, a three-day music and dance festival in Nagpur was organized by the Indian government's South-Central Zone Cultural Centre (SCZCC) in Deshpande's memory.

Renowned Hindustani classical vocalist and distinguished Akhil Bhartiya Gandharva Mahavidyalaya Mandal [21] alumni, Pandit Dr. Vasantrao Deshpande, left an indelible mark on Natya Sangeet with his exceptional talent.