Vasile Iordache was born on 5 November 1946 in Iași, Romania and started playing football at the junior center of local club Politehnica under coach Mihai Bârsan, making his senior debut in Divizia A on 24 August 1969 in a 2–0 away loss to Farul Constanța.

He was sent on the field by coach Gheorghe Constantin to replace Rică Răducanu in the 84th minute of the 3–0 victory against Sportul Studențesc București in the 1979 final.

[3][4][5][6][7][8][9][10][11] During his period spent with The Military Men, Iordache made a total of 231 Divizia A appearances, played 9 games in European competitions, competing to play for the team over the course of 12 seasons with other international goalkeepers like Narcis Coman, Carol Haidu, Dumitru Moraru and Rică Răducanu, also having a controversial moment when he got upset and left the field during a game with Argeș Pitești after conceding a goal because his defenders did not intervene, coach Jenei being forced to send Moraru to substitute him.

[3][4][5][6] Vasile Iordache played 23 matches in which he conceded 27 goals at international level for Romania, making his debut on 12 May 1976 under coach Ștefan Kovács in a 1–0 loss in front of Bulgaria at the 1973–76 Balkan Cup final.

[6][7] Iordache was chosen by Mircea Lucescu to be part of Romania's squad for the Euro 1984 final tournament but did not play as Silviu Lung and Dumitru Moraru were the first-choice goalkeepers before him.