Vaupés (Spanish pronunciation: [bawˈpes]) is a department of Southeastern Colombia in the jungle covered Amazonía Region.

It is located in the southeast part of the country, bordering Brazil to the east, the department of Amazonas to the south, Caquetá to the west, and Guaviare, and Guainía to the north; covering a total area of 54,135 km2.

During the colonization by the Spanish and first days of the first republic, the territory of Vaupes was part of the Province of Popayán, during the Greater Colombia.

[7] The department's main economic activities feature logging and fishing, with much exportation to neighboring Brazil.

Amazonas Antioquia Arauca Atlántico Bolívar Boyacá Caldas Caquetá Casanare Cauca Cesar Chocó Córdoba Cundinamarca Guainía Guaviare Huila La Guajira Magdalena Meta Nariño N. Santander Putumayo Quindío Risaralda San Andrés Santander Sucre Tolima Valle del Cauca Vaupés Vichada