Vayres-sur-Essonne (French pronunciation: [vɛʁ syʁ ɛsɔn] ⓘ, literally Vayres on Essonne) is a commune in the Essonne department in Île-de-France in northern France.

Prior to 1 January 1968, Vayres-sur-Essonne was part of the Yvelines department.

Inhabitants of Vayres-sur-Essonne are known as Vayrois.

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