Veľká Mača (Hungarian: Nagymácséd) is a village and municipality in Galanta District of the Trnava Region of south-west Slovakia.

The municipality lies at an elevation of 124 metres and covers an area of 14.813 km².

Before the establishment of independent Czechoslovakia in 1918, it was part of Pozsony County within the Kingdom of Hungary.

After the Austro-Hungarian army disintegrated in November 1918, Czechoslovak troops occupied the area, later acknowledged internationally by the Treaty of Trianon.

Between 1938 and 1945 Veľká Mača once more became part of Miklós Horthy's Hungary through the First Vienna Award.