[2][3] The series portrays the life of everyday people in Mexican barrios, where anything can be found — the jealous housewife, the spinster, the strange family, etc.

Each episode features the interactions between these peculiar neighbors, where they deal with problems both real and imagined, such as ghosts, treasures, ripoffs, fights, etc.

[6] When Eugenio Derbez traveled to Spain in 2005, he saw a TV series named Aquí no hay quien viva, which features the same kinds of problems that people have in the barrios.

[10][11] In January 2019 executive producer Elias Solorio announced on his Twitter account that filming of the sixth season had begun.

[18] On 17 March 2024, it was announced that a spin-off focused on the López Pérez family was in the works for Vix.