Vedène (French pronunciation: [vədɛn]; Occitan: Vedena) is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in southeastern France.

It is a northeastern suburb of Avignon, crossed by the A7 autoroute.

It is home to the Regional 1 football club Athlétic Club Vedène Le Pontet.

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