The race has a course on winding roads through the two Veluwe national parks, Hoge Veluwe National Park and Veluwezoom National Park, and the Nederrijn river valley in the south east corner of Utrecht province over a distance of roughly 209 km, interspersed with little steep cobbled climbs, the most significant of which are the Grebbeberg and the Posbank in Rhenen, and the Emma Pyramid in Rozendaal.

However the event was moved to yet another new date in 2006, with the race taking place in June, away from the congested spring classics calendar and no longer competing in the same midweek with the Scheldeprijs.

In 2005 Veenendaal–Veenendaal benefited from the creation of the new UCI ProTour structure when it was elevated to 1.HC standard bringing to the same level as Belgium's Omloop "Het Volk" and Germany's Rund um den Henninger Turm, thus bringing more sponsorship and publicity.

[2] From 2014 onwards, the race became known in Dutch as the Arnhem–Veenendaal Classic, reflecting a new start location in Arnhem.

The 2025 edition of the race will not take place owing to a lack of police availability due to the NATO summit at The Hague.