Velké Žernoseky is a municipality and village in Litoměřice District in the Ústí nad Labem Region of the Czech Republic.

Velké Žernoseky is located about 4 kilometres (2 mi) west of Litoměřice and 14 km (9 mi) south of Ústí nad Labem.

The highest point is the hill Strážiště at 362 metres (1,188 ft) above sea level.

The first written mention of Velké Žernoseky is in the foundation deed of the Litoměřice Chapter from 1218.

It belongs to the Litoměřická wine sub-region and is one of the northernmost wine-growing places in Europe.