[3] Velké Březno is located about 7 kilometres (4 mi) east of Ústí nad Labem.

It lies in Central Bohemian Uplands and in the eponymous protected landscape area.

The highest point is the hill Kočičí vrch at 525 m (1,722 ft) above sea level.

The first written mention of Velké Březno is from 1167, when the area became property of the Knights Hospitaller.

For financial reasons they were forced to sell the village in 1520 to the Salhausen family, then the owners often changed.

Today the brewery is owned by Heineken N.V..[6] Velké Březno is located on the railway line Ústí nad Labem–Děčín.