Velké Pavlovice (German: Groß Pawlowitz) is a town in Břeclav District in the South Moravian Region of the Czech Republic.

Most of the municipal territory lies the Ždánice Forest range, only the southern part extends into the Lower Morava Valley and Kyjov Hills.

The first written mention of Velké Pavlovice is from 1252, when the settlement gave tithes from vineyards to the newly founded Cistercian abbey in Žďár nad Sázavou.

During the Thirty Years' War, Velké Pavlovice was one of the worst damaged villages in the region.

[2] In 1891 Velké Pavlovice was promoted to a market town by Emperor Franz Joseph.