Undoubtedly the most significant event in the Jewish community of Mezhirichi was the arrival there of the Maggid, Rabbi Dov Ber.

After the death of the founder of Hasidism, the Baal Shem Tov, in 1761, Rabbi Dov Ber became the next leader of the movement.

The location of Mezhrichi, nearer to Poland and White Russia than the Baal Shem Tov's seat in Medzhybizh, acted as a spur to the fledgling chasidic movement.

However, archaeologists found in the area a settlement of Bronze Age and the Roman coins of II century AD.

The Magdeburg rights were provided for the village Mezhyrichi by the King of Poland Sigismund III Vasa in 1605.