The railway infrastructure is managed by the Rete Ferroviaria Italiana, which classifies it as one of its primary lines.

[5] The electrification of the Mestre–Udine section at 3000 volts DC was officially inaugurated in October 1960.

The major cities crossed, in addition to the two termini, are Treviso and Pordenone.

The line is signalled with the Sistema di Comando e Controllo (SCC), a form of centralized traffic control.

Traffic is regulated by an operations centre manager at Venezia Mestre.