Growing up in Kunnumpuram behind the Ayurveda College in Thiruvananthapuram, Venu Rajamony completed his primary education in Holy Angels Convent.

[7] Moving to New Delhi to pursue a Master's degree in International Studies from Jawaharlal Nehru University (JNU), he served as Vice President of the Students' Union there during 1981 and 1982.

[10] During his tenure in the Netherlands, Rajamony represented India before the ICJ in The Hague in the case of "Advisory Opinion concerning the Legal Consequences of the Separation of the Chagos Archipelago from Mauritius.

[16] Additionally, he led the Indian delegation to various sessions of the Conference of States Parties and Executive Council of the OPCW.

He is tasked with exploring opportunities for external cooperation in sectors such as business, trade, investments, finance, skill development, education, and culture.