The manga has been licensed for English language distribution by North American–based company Seven Seas Entertainment; the first volume was released in July 2007.

The series has since been adapted into an anime produced by Studio Hibari that aired in Japan between January and March 2007 on BS-i, consisting of twelve episodes.

Venus Versus Virus began as a manga series first serialized on June 27, 2005 in the shōnen magazine Dengeki Comic Gao!

[11] A drama CD based on the manga series was first released in Japan on October 25, 2006 produced by Frontier Works.

[22] ADV Films had also licensed Venus Versus Virus for release in Germany, but the DVDs were put on hold.