From 1914 to 1919, Vera Karalli would appear in approximately sixteen Russian silent films, including the 1915 adaptation of Leo Tolstoy's War and Peace titled Voyna i mir.

Her last film appearance was in a German dramatic release entitled Die Rache einer Frau (English title: A Woman's Revenge) in 1921.

[citation needed] Karalli was a mistress of Grand Duke Dmitri Pavlovich of Russia and was reportedly also a co-conspirator in the December 1916 murder of Grigori Rasputin.

[3] After fleeing to the West following the October Revolution, Karalli made her final film appearance in the 1921 Robert Wiene-directed German silent drama Die Rache einer Frau opposite Olga Engl and Franz Egenieff, credited as "Vera Caroly".

[citation needed] In 1920, Karalli participated in a large charity concert at the Paris Opéra along with opera singer and dancer Maria Nikolaevna Kuznetsova amongst others, to raise funds to aid impoverished fellow Russian émigrés.