She obtained her PhD (1958) and DSci (1978) degrees at the Bulgarian Academy of Sciences (BAS) in Sofia.
Her research focused on the Ottoman period on which she published dozens of studies in Bulgarian and European journals.
[6] She was also the scriptwriter of the 1981 film Khan Asparuh[7] (4th most viewed movie in Bulgaria of all time and official submission of Bulgaria for the 'Best Foreign Language Film' category of the 55th Academy Awards in 1983;[8] international title 681 AD: The Glory of Khan[9] ) and of two other films on contemporary subjects,[10] as well as of "The Road", a drama on the second Bulgarian Kingdom.
From 1997 to 1998, Mutafchieva was head of the State Agency for Bulgarians Abroad.
[1] Mutafchieva died at the Lozenetz Hospital in Sofia at the age of 80.