As Charles died without issue in 1691, Vere inherited the Earldom of Westmorland.

[3] The couple had eleven children: Fane died on 29 December 1693, probably from complications that arose from diabetes.

[4] His oldest surviving son Vere inherited his father's earldom and further titles, but died without issue before reaching the age of 20.

As was common in his family[4] (his grandfather Francis, his father Mildmay and his older brother Charles had been Members of Parliament before they became earl; his sons John and Mildmay would do so as well[8][2]), Vere Fane served as a Member of Parliament.

[4] At the coronation of King Charles II on 23 April 1661, he was invested as a Knight of the Bath.