The Vermilion Estate is a historic building located in Centerville, Iowa, United States.

[2] The Italianate style structure was designed for the Vermilions by Burlington, Iowa architect C.A.

Completed in 1870, the two-story frame house rests on a stone foundation, has bracketed eaves, and is capped with a hipped roof.

It was originally a 40-acre (16 ha) estate, and Dr. Vermilion did rely on livestock or horses for part of his livelihood.

This article about a property in Appanoose County, Iowa on the National Register of Historic Places is a stub.