When settlers first arrived in the area, the saline springs were the basis of the dominant industry.

The Middle Fork arises near Roberts, and flows southeast toward Danville.

The Middle Fork is notable as the only river in Illinois designated as a National Wild and Scenic River by United States National Park Service.

This scenic stream flows through Kickapoo State Park near Danville and is a favorite of Illinois canoeists.

The North Fork arises in Indiana to the northeast of Hoopeston, Illinois.