Route 225 most practically serves as part of a connection between Vermont and the city of Saint-Jean-sur-Richelieu in Quebec, located about 31 mi (50 km) southeast of Montreal, Quebec.

Quebec Route 225 ends in Sainte-Anne-de-Sabrevois, roughly eight miles (13 km) from Saint-Jean-sur-Richelieu.

[citation needed] VT 225 is essentially a northern spur of US 2, which approaches running northward through the town of Alburgh.

US 2 turns westward towards its final approach to New York, and VT 225 begins to the north.

Both of these intersections occur within a quarter mile of VT 225's southern terminus.