It is considered a "fundamental" line by the state railways Ferrovie dello Stato (FS).

[4] The railway infrastructure is controlled and managed by Rete Ferroviaria Italiana a subsidiary of FS.

Difficulties in the construction of the embankment near San Felice sul Panaro and the presence of numerous aquifers along the way which made the terrain over which the line had to pass unstable caused its continuation to be built as a single track.

[6] During those same years, the trunk line between San Felice and Verona Porta Nuova station was the subject of bitter controversy.

The original project designed by the engineers Minarelli and Jean Louis Protche and approved by the legislature, was routed through Poggio Rusco.

As a result, the Suzzara–Ferrara railway company started construction only a few weeks later of a variation of the project that allowed it to join the Verona-Bologna line at a future station in the town of Poggio Rusco.

[7] Following the financial crisis of the 1890s work proceeded slowly and Poggio Rusco was reached on 20 January 1902.

Four rail cars were constructed by Diatto with two Ganz 30 kW electric motors, and with 52 seats.

The building continued to be slow: Revere Scalo was reached on 23 July 1909, while the bridge over the Po river and the Ostiglia Station were opened on 26 November 1911.

The 1 February 1924 the line was opened between Isola della Scala and Saint Lucia junction,[6] where it separates from the Verona–Mantua railway.

At this point it crosses several different lines: After Saint Lucia junction, the railway runs through a long straight section that leads to the town of Isola della Scala.

The latter has been closed and during the duplication of the line it was turned into a crossover, where trains can change tracks as required.

At station of Isola della Scala occurs at the intersection with the Verona–Rovigo line, which since 1985 has only run towards Cerea, while the section towards Dossobuono has been abandoned and partially dismantled.

The old Ostiglia station was formerly the location of a junction with the former line to Legnago and Treviso, which was destroyed by allied bombing during World War II.

The old line between Revere Scalo yard and the Poggio Rusco station remain active.

After Crevalcore, the railway turns to the south-east and runs parallel to that of Highway 568 via San Giovanni in Persiceto and Tavernelle d'Emilia.

Regional passenger services are managed by Trenitalia with the collaboration of Ferrovie Emilia Romagna on the section between Poggio Rusco and Bologna.