She is known as an outspoken liberal and an advocate of European integration, anti-fascism, gender equality and LGBT rights.

During her 2008–2011 parliament term she chaired the parliamentary committee for tracking the progress of Croatia's accession negotiations with the European Union.

[2] In 1984, she obtained a doctorate in sociology at the same faculty (PhD Thesis: "The Role of Collective Decision-making in the Realization of Workers' Interests").

[3] In 1978, Pusić was one of seven women who initiated the first feminist organization in SFR Yugoslavia Žena i društvo (Woman and society) and was widely criticized by the authorities at the time.

After Kukuriku coalition won the 2011 parliamentary elections, Pusić served as Minister of Foreign and European Affairs in the center-left Cabinet of Zoran Milanović.

She continued to be an MP until the 2020 parliamentary election, when she chose to retire from politics instead of opting to run for re-election.

This gross problem was brought to light after Anders Kompass exposed the sexual assault of children by peacekeepers in the Central African Republic.

Pusić repeatedly referred to the three reports that have addressed peacekeeping SEA, citing that she would follow and implement much of the same principles.

On the question of the Hungarian ambassador to the UN concerning which way of leadership is needed by the UN and the world, Pusić replied that standards have dropped in the past 20 years, stating that "phrases and lack of accountability are currently very popular.

She stated that she wanted to be Secretary-General because the UN topics of peace, human rights and development have taken center stage throughout her life.

[13] When commenting on the UN's International Criminal Tribunal for the former Yugoslavia (ICTY), she stated that the court wasn't perfect, but that it would have been much worse without it, adding that it sent an important message; "If you commit a war crime, you will be caught.

[15] After receiving 11 'discourage' votes on a first informal closed-door straw poll of the 15-member UN Security Council that was held on 21 July 2016, Pusić decided on 4 August 2016 to withdraw from the race and focus on the 2016 extraordinary parliamentary elections.