Along with Friulano, Vespaiola is an important component in the Denominazione di origine controllata (DOC) white wine of Breganze produced in the province of Vicenza.

The varietal wine Vespaiola must be made entirely of the single variety, harvested to more limited yields and produced with a higher alcohol level.

[4] The name Vespaiola is derived from the Latin vespa and refers to the wasps that are attracted to the high sugar content in the grapes as they ripen late into the growing season.

[6] The wasps' presence can be considered a viticultural hazard due to not only their propensity to damage the grapes in order to get to the sweet pulp inside, but also the danger they may cause to vineyard workers in the area.

[6] The passito styles of Vespaiola are characterized by a golden color with aromas of apricots, honeysuckles and spice that can be a byproduct of aging in oak.