Vestal is a town within Broome County in the Southern Tier of New York, United States, and lies between the Susquehanna River and the Pennsylvania border.

The central area of Vestal, near Route 26 at Choconut Creek, was the site of an indigenous village of the Ochugnut tribe of the Tuscarora people.

During the American Revolution, a squad of soldiers from the Sixth Massachusetts Regiment, under the command of Lt. William McKendry[9] were sent to engage the tribes, when possible, and destroy their homes and crops.

This campaign during the American Revolution was initiated following Indigenous predations against settlers, presumed to have been carried out by tribes forming part of the Iroqouis alliance.

[12] In 1901, on June 8, Vestal was the location of a huge explosion of dynamite aboard a train of the Delaware, Lackawanna and Western Railroad.

During the 20th century, Vestal served as a residential suburb to emerging industries in its area, such as Endicott Johnson Corporation, IBM, and Lockheed Martin.

[7][14][15] The college, part of the SUNY system, moved from Endicott to Vestal by 1961, and has since grown significantly and been renamed Binghamton University.

Vestal's historic central business district is located along three blocks of Front Street, still lined with small shops.

The Drovers Inn and Round Family Residence and Vestal Central School were listed on the National Register of Historic Places in 2010.

New York State Route 201 also crosses to the north shore of the Susquehanna River, linking the eastern part of Vestal with the village of Johnson City.

Vestal had been a stop, midway between Binghamton and Owego, on the Delaware, Lackawanna and Western's mainline, serving passenger trains such as the Phoebe Snow.

The VPD shares a joint special response team with other Broome County agencies, a K-9 unit, detectives, and bicycle patrol.