It is a four-year comprehensive school which annually receives both national and state recognition for excellence in education.

Clubs and student organizations accommodate a wide range of interests, from the physical sciences to martial arts.

The program has become increasingly popular at Vestal High School with the majority of the students taking at least one AP, IB, or Honors course.

To be eligible, a student must take and pass a minimum of six IB, AP, or Excelsior College courses.

Vestal Boys' Soccer completed a 20-0 season by winning the State Class A Championship over Queensbury at Middletown High School on November 12, 2017.

On November 18, 2007, the Vestal Boys' Soccer team captured the Class AA New York State Championship.

Vestal's Men's Varsity Golf Team won the Southern Tier Athletic Conference title three years in a row from 2010 until 2012, with one College signing to St. Bonaventure.

Sports Include: Football, Tennis, Golf, Cross Country, Volleyball, Field Hockey, Cheerleading, Soccer, Swimming, Bowling, Basketball, Indoor track, Wrestling, Baseball, Softball, Lacrosse, Track and Field, and club Ice Hockey.

Many students have auditioned successfully in the New York State Schools Music Association (NYSSMA), with a few selected into All-State Festival ensembles,[28] and a nationwide honors orchestra at the Festival of Gold conducted by Keith Lockhart, the conductor of the Boston Pops Orchestra.

Many also participate in the Broome County Music Educators Association (BCMEA) Festival and the Binghamton Youth Symphony Orchestra (BYSO).

The art department at Vestal High School has produced some of the best student artists in the area.

In 2011, many students were named finalists and runners-up at the 2011 Arnot Art Museum ceremony, including a Gold Key Award by Dillon Utter, class of 2011.