After the latter one disintegrated into smaller feudal domains, the area subsequently passed through the Rostov, Uglich, Yaroslavl, and Beloozero principalities, before ending up in the Grand Duchy of Moscow in the 15th century; by the end of the 15th century, the Novgorod Republic was annexed by Moscow as well.

[8] On April 25, 1921, Vesyegonsky Uyezd was transferred to newly established Rybinsk Governorate.

Vesyegonsky District, with the administrative center in the town of Vesyegonsk, was established within Bezhetsk Okrug of Moscow Oblast.

On March 5, 1935 a new division of Kalinin Oblast was introduced, and the area of Vesyegonsk District was reduced.

[9] In 1939, the construction of the Rybinsk Reservoir started, and large areas in the lower course of the Mologa were to be submerged under water.

The main specialization of agriculture is cattle breeding with meat and milk production.

[11] A railway connecting Moscow and Mga via Sonkovo and Pestovo crosses the southern part of the district.

[8] Vesyegonsk is connected by roads with Ustyuzhna and with Tver via Krasny Kholm and Bezhetsk.

[12] The federal monuments are the Presentation Church of the early 19th century in the selo of Churikovo and an archeological site.