Vezzano Ligure (Italian: [vetˈtsaːno ˈliːɡure]; Ligurian: Vessan, locally V'zan) is a comune (municipality) in the Province of La Spezia in the Italian region of Liguria, located about 80 kilometres (50 mi) southeast of Genoa and about 7 kilometres (4 mi) northeast of La Spezia.

Vezzano Ligure borders the following municipalities: Arcola, Bolano, Follo, La Spezia, Santo Stefano di Magra, Sarzana.

Tourism is also active, as well as service companies working for the La Spezia intermodal port.

Vezzano Ligure is served by a railway station on the lines Genoa-Rome and Parma-La Spezia located downhill from the center of the old town.

The nearest motorway is the A15 with a marked westbound exit and eastbound entrance between Santo Stefano and La Spezia.