At the end of World War I, footballers received some tutoring from an unlikely source in the form of an English officer in charge of prisoners-of-war locally.

VfB Eppingen was established as a separate club devoted to football in 1921 and went on to win the local Gau title in 1925.

Eppingen enjoyed a successful decade in the 1970s beginning with a 2.Amateur Liga Rhein-Neckar championship in 1973 and following up with Amateurliga Nordbaden titles in 1974 and 1979.

A highlight of the club's history in this period was their 2:1 win over Hamburger SV in the 1974–75 German Cup, commonly dubbed the "mother of all cup sensations", which was part of their run through first three rounds of the competition to the Achtelfinale (round of 16) where they were finally put out 0:2 by Werder Bremen.

Another relegation from the Verbandsliga meant VfB would return to the Landesliga in 2014 where it won a league championship in 2015–16 and was promoted.