The central characters, known as "radio's home folks", were accountant Victor Rodney Gook, his wife Sade (Bernardine Flynn) and their adopted son Rush (Bill Idelson).

In 1940, the actor who played Vic, Art Van Harvey, became ill, and Sade's Uncle Fletcher (Clarence Hartzell) was added to the cast to fill the place of the missing male lead.

During World War II, the actor who played Rush, Bill Idelson, was called into military service, and he left the show.

The spring months of 1943 were a tumultuous period, but eventually a second son figure, Russell Miller (David Whitehouse), was brought in, and the program continued as it always had.

Rhymer evidently felt some pressure from the sponsor's advertising agencies to include more romance and human interaction in his scripts, like the other daytime dramas on the air.

He complied by adding ridiculous touches (his romantic lead, Dwight Twentysixler, always speaks with his "mouth full of shingle nails"!)

[2] In 1957 a series entitled The Humor of Vic 'n' Sade ran for seven weeks, returning to the original three-character format with 15-minute episodes, a multi-camera setup and a small, stripped-down, bare set.

The following characters were not portrayed by actors until very late in the show's run (and rarely even after that) but were frequently discussed by Vic, Sade, Rush and Uncle Fletcher.

Guest, Ogden Nash, John O'Hara, Fred Rogers,[6] Franklin Delano Roosevelt, Jean Shepherd, James Thurber, Tom Lehrer and Hendrik Willem van Loon.

Bernardine Flynn said the show once received a letter from a judge who called a recess each afternoon so he could listen to Vic and Sade.

In addition to Rhymer himself, directors included Clarence Menser, Earl Ebi, Roy Winsor, Charles Rinehardt, Homer Heck, and Caldwell Cline.