[3] Major international recording artists have performed in Vicar Street including Bob Dylan in 2000,[4] Neil Young in 2003, Adele in 2008,[5] Paul Simon and Ed Sheeran in 2011, and Lana Del Rey in 2013.

In 2008, Canadian indie rock band Wolf Parade's November show which had been scheduled for Andrew's Lane Theatre was moved to Vicar Street.

[11] In March 2009, the Irish Anti-War Movement hosted a fund-raising event at Vicar Street, featuring Christy Moore, Stephen Rea, Sinéad Cussack, Róisín Elsafy, Mick Pyro, Judith Mok, and Joyce.

[12] A Musicians For Marriage Equality show featuring artists such as Michele Ann Kelly and The Spikes took place at Vicar Street in October 2009.

Many comedians and musicians, both from Ireland and abroad, have chosen to record some of their live material at the venue including Simon Amstell, Aslan, Des Bishop, Jason Byrne, Damien Dempsey, The Dubliners, Erasure, The Frames, Andy Irvine's 70th birthday concerts, Kíla, Christy Moore, Dylan Moran, Moving Hearts, Mundy, Planxty, Josh Ritter, Tommy Tiernan, Neil Young, Dara Ó Briain, and Foil, Arms & Hog.