Per Article 37 of the Constitution of Tanzania, if the president dies, resigns, is permanently incapacitated, or is disqualified, the vice-president ascends to the presidency for the balance of the term.

If the vice-president ascends with more than three years remaining, they are only eligible for one full term.

[3] For example, when Samia Suluhu Hassan became the first vice-president to directly ascend to the presidency, she did so only one year after being reelected as the running mate of her predecessor, John Magufuli.

While she would be eligible to run for a full term in 2025, if she won she would have to leave office in 2030.

After the union between Tanganyika and the People's Republic of Zanzibar to form the United Republic of Tanzania in 1964, Tanzania had two vice-presidents, First and Second until the creation of a single office in 1995.