[5] His maternal grandmother was a diplomat, and as a result, his mother was mostly raised in Chile, where she met and married his father before relocating to the United States.

[9] Luque began training in various forms of martial arts as a youngster, initially karate at the age of three.

[10] When Vicente was six, his parents separated and he moved to Brazil with his mom, where he continued training karate until the age of ten.

[10] After a spell with soccer, he started training in Muay Thai and Brazilian jiu-jitsu as a teenager before transitioning to mixed martial arts in 2008.

[14] Luque made his official debut for the promotion on July 12, 2015, at The Ultimate Fighter 21 Finale, where he faced fellow castmate Michael Graves.

[28] Luque faced Niko Price, replacing an injured Luan Chagas on 11 day notice, on October 28, 2017, at UFC Fight Night: Machida vs.

[39] However, it was reported on May 13, 2019, that Magny pulled out of the bout due to testing positive for Di-Hydroxy-LGD-4033,[40] and he was replaced by newcomer Derrick Krantz.

[48] Luque was scheduled to face Randy Brown on April 11, 2020, at UFC Fight Night: Overeem vs.

[50] In a quick turnaround, Luque was scheduled to face Niko Price in a rematch on April 18, 2020, at UFC 249.

[51] However, on April 9, Dana White, the president of UFC announced that this event was postponed[52] and the bout eventually took place on May 9, 2020.

[54] The bout with Randy Brown was rescheduled and took place on August 1, 2020, at UFC Fight Night: Brunson vs.

[55] Utilizing low kicks and dropping Brown multiple times, Luque eventually won the fight via knockout in the second round.

[58] After hurting Woodley multiple times on the feet, Luque won the fight via D'Arce choke submission in round one.

[70] However, the pair was moved to instead fight on August 12, 2023, at UFC on ESPN: Luque vs. dos Anjos for unknown reasons.

[75] However, Brady indicated he never signed a bout agreement due to dealing with an injury,[76] and was replaced by Joaquin Buckley.

[78] Luque was scheduled to face former WEC and Strikeforce Welterweight Champion Nick Diaz on August 3, 2024 at UFC on ABC 7.

[80][81] In turn, Diaz withdrew from the bout due to unknown reasons and was replaced by Themba Gorimbo.