Vicente de la Osa (January 6, 1808 – July 20, 1861), baptized Jose Vicente de los Reyes de la Ossa, was a Californio city official, tavern owner, and cattle rancher who owned Rancho Providencia and Rancho Los Encinos in what is now the San Fernando Valley area of Southern California in the United States.

De la Osa was born at the Presidio of San Diego, where his father was a corporal.

[1] After the decline of the California Gold Rush-fueled cattle boom, de la Osa "compensated by establishing a small vineyard, raising some sheep, and letting out rooms to travelers".

[3] In 1856 and 1859 he held a relic political position called Judge of the Plains that adjudicated disputes between ranchers.

[1] De la Osa died in 1861 leaving a pregnant wife with 12 children; Rita de la Osa later sold Rancho Los Encinos to one of her daughters and a son-in-law who served as Los Angeles county sheriff.