Knight debuted as an actress from Sacha Polak's Dirty God, where she played an acid attack victim.
She started a charity named "Scar Quality" to help others who have experienced burns improve their self-esteem.
[5] Vicky Knight received burns to 33 per cent of her body and was left severely disfigured.
[6] In 2014, Knight appeared in an episode of the British dating television show Too Ugly For Love.
[11] She later stated that she was deceived into appearing on the programme as the producers initially told her it would focus on the everyday realities of her life as a burns survivor.
[6] When she complained to the production company about the trolling, she was invited to take part in the British matchmaking TV programme The Undateables.
Tara Brady of The Irish Times wrote, "Knight delivers a terrific performance that is as complex as the sometimes maddening, frequently stupid, and always sympathetic character that she plays.
"[14] Writing for Variety, Jay Weissberg wrote, "a stand-out performance from newcomer Vicky Knight and an unflinching portrait of a strong-willed yet immature protagonist facing a radical change in how the world looks at her as well as how she sees herself.
"[15] Playing the role was emotionally difficult for Knight, who said in an interview "I had quite a few breakdowns on set so all the tears that you see are real".
[10] Knight stated Dirty God changed her life entirely in helping her to cope with her burn scars.
[2][3][9] Knight added she finds it difficult to enter the emotions concerning her scars "[I] Emailed doctors in India and Turkey, asking them to help me".
[19] She attended Robert Clack School,[2] followed by Barking and Dagenham College in London, England, where she studied Health and Social Care.
[20] Knight set up a charity, "Scar Quality", in 2013, to help those who have experienced burns improve their self-esteem.