After making his first-team debut in September 2013, he continued to appear for the club at B level, while also winning three Primeira Liga titles.

[8] In October 2009, at the age of 15, Lindelöf made his first-team debut for Västerås SK, when the team beat BK Forward 3–0 in the last round of the 2009 Division 1 Norra season.

[14] On 16 February 2016, he played the entire match for Benfica in a 1–0 home win against Zenit Saint Petersburg in the first leg of UEFA Champions League's round of 16.

[23] He was limited to just 17 premier league matches, starting 13 of them, due to Jose Mourinho's preference of playing a defensive partnership of Chris Smalling and Phil Jones.

[27] On 1 December 2019, he played 90 minutes and scored his only goal in the season in a league match against Aston Villa that ended 2–2 draw.

[31] He played the full 90 minutes on 2 February 2021 in Manchester United's Premier League record-equalling 9–0 home win against Southampton.

[33] Lindelöf spent the majority of the season serving as a backup to Lisandro Martínez and Raphaël Varane, alongside Harry Maguire,[34] until the centre-back pairing both fell injured in a 2–2 UEFA Europa League draw with Sevilla in April.

[35] Promoted to first-choice, he would play the full 120 minutes of Manchester United's FA Cup semi-final victory against Brighton & Hove Albion on 23 April, where he scored the winning penalty in the shootout which ended 7–6 in United's favour, securing a place in the final against Manchester City.

[38] On 11 November 2023, Lindelöf scored his first goal for Manchester United since December 2020 in a 1–0 win over Luton Town at Old Trafford.

[citation needed] Although Lindelöf was not named in the final squad for the UEFA European Under-21 Championship, on 15 June 2015 he replaced defender Emil Krafth who was ruled out of the tournament after a back injury.

[46] Lindelöf scored his first international goal for Sweden in a 3–0 win over Bulgaria in a 2018 FIFA World Cup qualifier at Friends Arena in Stockholm on 10 October 2016.

[48] Lindelöf missed the first game against South Korea due to illness, but was a regular starter in defense alongside fellow centre-back Andreas Granqvist for the remainder of the tournament.

[58] In January 2022, while Lindelöf was playing the full 90 minutes against Brentford in a 3–1 win, his Manchester home was broken into by intruders whilst he was on the pitch.