She founded the rock band Måneskin in 2016 in Rome alongside guitarist Thomas Raggi, lead vocalist Damiano David, and drummer Ethan Torchio, with whom she won the Sanremo Music Festival 2021 and subsequently the Eurovision Song Contest 2021 for Italy with the song "Zitti e buoni".

[3] During an interview for Elle, she revealed she suffered from panic attacks at age 14,[4] which caused her to miss a year of school.

Ethan Torchio who lived in nearby Frosinone joined them when they advertised for a drummer on Facebook to complete the line-up.

[13] They later performed as buskers in the streets of the Colli Portuensi district of Rome, and in 2017, they rose to prominence when they finished second in the eleventh season of the Italian talent show X Factor.

The band had a breakthrough debut with the studio album Il ballo della vita and tour in 2018 and 2019.

[19] De Angelis identifies as lesbian, having previously as bisexual, saying her identity is developing, and is in a relationship with model Luna Passos.