[2] Shortly after its completion, Batman provides her with access to the Belfry, his high-technology headquarters atop Old Wayne Tower in downtown Gotham City.
Four of them merge into a composite monster at the end of the story, but it is defeated by Batman, Nightwing, Batwoman, Orphan, Spoiler, and Clayface (Basil Karlo).
[3] She asks Clayface to stay in his monstrous form for as long as possible so she can chart the mental degradation he undergoes the longer he remains nonhuman.
[11] Dr. October gives him a "placebo" bracelet with messages from his close friend Cassandra Cain (Orphan), which helps him focus on retaining his sanity.
Dr. October expresses a desire to test her cure serum on a less serious case, and Karlo told her of Glory Griffin (the villain Mudface), who was doused in the same chemicals that made Clayface what he is.
[15] Later, with the cure close to being finished, Clayface is captured by Glory when the villain First Victim takes over Arkham Asylum and releases her.
Karlo watches as Cassandra Cain takes up residence at a health clinic in one of Gotham's slums run by Dr. Leslie Thompkins.
Unfortunately, Lena's ship was lost in time, and Lex Luthor demanded that the Soviet authorities arrest October and Dugan.
[27] Just before the war broke out, she attended a "Conference on the Ethics of Bioweaponry" in Paris, France, where her presentation was witnessed by Pamela Isley (the Bombshell Universe version of the villain Poison Ivy).
[25] Dr. October alerts Lois Lane and the others in Harley's group to Hugo Strange's experiments on political prisoners, particularly one bioweapon (the Bombshell Universe version of Power Girl) that appears at night to attack the Nazi army.
She gives Lois and Andrea Grüener (the Bombshell Universe's female version of Dr. Benjamin Gruener—the villain known as The Reaper) a device to find this bioweapon.
Riding a firebird,[l] Dr. October retrieves Varvara Dugina (Supergirl's adoptive mother) from the American refugee center where she's been hiding, Ipati Dugan (Supergirl's adoptive father) from the Soviet gulag where he was imprisoned, and Samuel Whitmore (biological father of Bombshell Universe's Stargirl)[m] from his home in London.
[n] Supergirl and the Beefcake Superman destroy the kryptonite knife with their heat-vision, and Zatanna, John Constantine, and Raven to imbue the lesovik, Swamp Thing, with its radioactivity.
To make the magic work, Varvara, Ipati, and Whitmore give up their lives, thus imprisoning Doomsday forever inside Swamp Thing.
[33] Dr. October has a cameo in DC Comics Bombshells #100, appearing in Pamela Isley's garden as the Siege of Leningrad is lifted.
But Kelsey Loiselle, reviewing Dr. October's early appearances in Detective Comics, argued that writers James Tynion IV and Marguerite Bennett worked hard to ensure that Dr. October's appearances did not "us[e] transgender conversation to bolster...sales" but rather used them to discuss the meaning of identity and what it means for superheroes and readers.
[35] Reviewer Andrew Dyce called Dr. October's introduction one of "beauty, elegance, and dignity", rather than a "reveal" meant to grab headlines and get attention.
[36] He praised Dr. October's first two appearances, arguing "it isn't Detective Comics' goal to simply acknowledge transgender individuals' existence.
[37] Reporter Marissa Higgins, writing for web site The Daily Dot, noted "how important it is for people to have representation that feels real".
Higgins applauded how the comic provided these details as character history and avoided making transgender identity "the all-consuming present and future" of Dr.
Brown writes, Batman's action enables readers (especially men) to see gender transition as appropriate behavior and transgender individuals as "perfectly normal" and worthy of respect.