She is known for her role as Sally Smedley in Channel 4's comedy series Drop the Dead Donkey (1990–1998), Mrs. Gideon in The Mighty Boosh (2004), and the College Director in Skins (2007–08).

Her first job was as acting assistant stage manager at Northampton Rep for a year, before going to Bristol Old Vic, Regent's Park and then the RSC.

In 1988 Wicks was in Andy Hamilton's black comedy Tickets for the Titanic, and then went on to play Sally Smedley in all six series of Drop the Dead Donkey.

[3] The Mighty Boosh (a radio, television and stage show created by Noel Fielding and Julian Barratt) featured her in Series 1 as Mrs Gideon, the Head of Reptiles at the Zooniverse.

Since joining the company Wicks has appeared in nine plays by Barker, performing in London, Berlin, Stockholm, Copenhagen, Adelaide and also in Rouen, Grenoble, Le Mans and Paris for the co-production of Les Animaux en Paradis, which was performed in French by four British and five French actors.