He relocated with his family from Carini, Sicily to the U.S. in July 1920, arriving at the Port of New York aboard the Italian steamship Patria.

Ten years later, he moved to Los Angeles and co-founded a big band with Stan Kenton in 1935.

[1][2] Musso left the band the following year to collaborate with Gus Arnheim, Benny Goodman, and Gene Krupa.

After returning to Goodman, he was a member of big bands led by Harry James, Woody Herman, and Tommy Dorsey.

[1] As a leader, Musso recorded for Savoy (1946), Trilon (1947), Arco, Fantasy (1952), RPM, Crown, and Modern.