The daughter of actor Mohan Raman, Vidyullekha made her debut in Gautham Vasudev Menon's 2012 Neethaane En Ponvasantham.

She gained her popularity doing stage productions during her college years at M.O.P.

[1] She made her debut in Gautham Vasudev Menon's 2012 bilingual films Neethaane En Ponvasantham and Yeto Vellipoyindhi Manasu, appearing as Jenny, a friend of the character portrayed by Samantha.

The actress has since played pivotal roles opposite N. Santhanam in Sundar C's Theeya Velai Seiyyanum Kumaru,[2] in Malini 22 Palayamkottai and the Telugu film Ramayya Vasthavayya.

[3] She emerged as the 3rd runner up in the cooking comedy show Cooku with Comali season 3.