Vignanello is a comune (municipality) in the Province of Viterbo in the Italian region of Latium, located about 60 kilometres (37 mi) northwest of Rome and about 14 kilometres (9 mi) southeast of Viterbo.

Vignanello borders the following municipalities: Corchiano, Fabrica di Roma, Gallese, Soriano nel Cimino, Vallerano, Vasanello.

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