She acted in many movies opposite Prem Nazir and have also worked in Tamil, Hindi, Telugu and Kannada films.

Her first film in Malayalam was Poojapushpam (1969), directed by the patriarch Thikkurissy Sukumaran Nair.

She also got to share screen space with the leading lady of the times, Sheela in her debut movie itself.

Her most notable films are Angathattu (1973), Postmane Kananilla (1972), Lanka Dahanam (1971), Maravil Thirivu Sookshikkuka (1972), Pacha Nottukal (1973), Taxi Car (1972), Aromalunni (1972) and Ponnapuram Kotta (1973).

He directed a film Naayika, by which the character in the movie named "Vani" (played by actress Sarayu) portrays slight resemblance to Vijayasree's life.

Her graceful statuesque beauty was almost a symbol of God's artistry", said actor Kaduvakulam Antony.

Many actors and directors said, due to the bad fate, Malayalam film fans could not see the great Jayan-Vijayasree combination on the screen.