Vila Mariana (Portuguese pronunciation: [ˈvilɐ maɾiˈɐnɐ]) is a borough of the city of São Paulo, Brazil.

Located to the south of Bela Vista and Liberdade, east of Jardim Paulista and west of Ipiranga, it is a dynamic area of the city.

Similar to its neighbor district, Moema, it is a wealthy area and it comprises some of the most famous symbols of São Paulo, like the Ibirapuera Park, the Obelisk and Mausoleum of the heroes from the Constitutionalist Revolution in 1932 and the "Monumento às Bandeiras", and the Fundadores de São Paulo monument.

Until the early 20th century, it used to be a stop for chariots and horse riders on the way to Jabaquara from the central area of São Paulo.

Vila Mariana is also the area where Athina Onassis lived, when married to Brazilian horse rider Álvaro Alfonso de Miranda Neto.